Quality of life in patients with chronic slow-transit constipation according to the PAC-QOL questionnaire and the effectiveness of conservative therapy

Authors

DOI:

https://doi.org/10.30978/GS-2024-2-18

Keywords:

chronic slow‑transit constipation, quality of life, PAC‑QOL questionnaire, conservative therapy, results

Abstract

Objective — to assess the quality of life (QOL) of patients with chronic slow‑transit constipation (CTC) according to the PAC‑QOL (Patient Assessment of Constipation Quality of Life) questionnaire, as well as the effectiveness of conservative therapy.

Materials and methods. The study included 246 patients with chronic (more than 5 years) slow‑transit constipation (CSTC group) and 70 patients without CSTC (reference group). These individuals were examined and treated in the clinics of Bogomolets National Medical University from 2014 to 2023. The onset of chronic slow‑transit constipation often occurred at an average age of 22.2±0.8 years (from 1 year to 67 years) and lasted 20.2±0.7 years (from 5 to 53 years). The average duration of the delayed passage of stool was 9.4±0.3 days (from 3 to 22 days). All patients received an adjusted course of conservative treatment according to the Rome guidelines. The nosospecific PAC‑QOL questionnaire was used to evaluate the patients’ quality of life on their initial visit and 6—8 months after conservative therapy.

Results. During the initial assessment, the CSTC group had a mean score of 3.03±0.56 on the «Physical Discomfort» subscale, while the reference group had a mean score of 1.19±0.29. On the «Psychosocial Discomfort» subscale, the CSTC group had a mean score of 2.21±0.52 compared to 0.84±0.18 in the reference group. The mean score for the «Worries and Concerns» subscale was 2.49±0.41 in the CSTC group and 0.77±0.24 in the reference group. The mean score for the «Satisfaction» subscale was 3.31±0.43 in the CSTC group and 0.86±0.28 in the reference group. The PAC‑QOL questionnaire total score was 2.63±0.26 in the CSTC group and 0.87±0.12 in the reference group (p <0.001 for all). After conservative treatment, the PAC‑QOL scores improved by an average of 40.4±20.0% (to 0.68—2.71 points). The cluster analysis revealed that after the course of conservative therapy, the PAC‑QOL questionnaire scores formed three distinct clusters: Cluster I — 0.68—1.39 points (49.2% of patients), Cluster II — 1.40—1.99 points (17.5% of patients), and Cluster III—2.0—2.8 points (33.3% of patients). These clusters represent good, satisfactory, and unsatisfactory results.

Conclusions. The PAC‑QOL questionnaire revealed a statistically significant decline in QOL in patients with CSTC (2.63±0.26 points compared to 0.87±0.12 points in the reference group). Modern conservative treatment improved quality of life in 49.2% of cases. 17.5% of cases showed a satisfactory result, while the remaining ones exhibited insignificant or no improvement. Other treatment options, including surgery, should be considered for patients who do not respond to conservative therapy.

 

Author Biographies

I. M. Leshchyshyn, Bogomolets National Medical University, Kyiv

-

L. Y. Markulan, Bogomolets National Medical University, Kyiv

PhD, Assoc. Prof.

O. I. Okhotska, Bogomolets National Medical University, Kyiv

-

P. L. Byk, Bogomolets National Medical University, Kyiv

-

References

Anti M, Pignataro G, Armuzzi A, et al. Water supplementation enhances the effect of high-fiber diet on stool frequency and laxative consumption in adult patients with functional constipation. Hepatogastroenterology. 1998;45(21):727-32.

Attar A, Lémann M, Ferguson A, et al. Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation. Gut. 1999;44(2):226-30. http://doi.org/10.1136/gut.44.2.226.

Aziz I, Whitehead WE, Palsson OS, Törnblom H, Simrén M. An approach to the diagnosis and management of Rome IV functional disorders of chronic constipation. Expert Review. Gastroenterology & Hepatology. 2020;14(1) :39-46. http://doi.org/10.1080/17474124.2020.1708718. Epub 2020 Jan 2.

Bellini M, Usai-Satta P, Bove A, Bocchini R, Galeazzi F, Battaglia E, Alduini P, Buscarini E, Bassotti G, and ChroCoDiTE Study Group, AIGO. Chronic constipation diagnosis and treatment evaluation: the «CHRO.CO.DI. T.E.” study. BMC Gastroenterology. 2017. http://doi.org/10.1186/s12876-016-0556-7.

Camilleri M, Ford AC, Mawe GM, Dinning PG, Rao SS, Chey WD, Simrén M, Lembo A, Young-Fadok TM, Chang L. Chronic constipation. Nat Rev Dis Primers. 2017;3:17095. http://doi.org/10.1038/nrdp.2017.95.

Cinca R, Chera D, Gruss HJ, et al. Randomised clinical trial: macrogol/PEG 3350+electrolytes versus prucalopride in the treatment of chronic constipation — a comparison in a controlled environment. Aliment Pharmacol Ther. 2013;37(9):876-86. http://doi.org/10.1111/apt.12278. Epub 2013 Mar 11.

Ford AC, Moayyedi P, Lacy BE, Lembo AJ, Saito YA, Schiller LR, Soffer EE, Spiegel BM, Quigley EM. American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. Am J Gastroenterol. 2014;109(Suppl 1):S2-26. quiz S27. http://doi.org/10.1038/ajg.2014.187.

Ford AC, Suares NC. Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: systematic review and meta-analysis. Gut. 2011;60(2):209-218. http://doi.org/10.1136/gut.2010.227132.

Gao R, Tao Y, Zhou C, Li J, Wang X, Chen L, Li F, Guo L. Exercise therapy in patients with constipation: a systematic review and meta-analysis of randomized controlled trials. Scand J Gastroenterol. 2019;54(2):169-77. http://doi.org/10.1080/00365521.2019.1568544.

Hajizadeh Maleki B, Tartibian B, Mooren FC, FitzGerald LZ, Krüger K, Chehrazi M, Malandish A. Low-to-moderate intensity aerobic exercise training modulates irritable bowel syndrome through antioxidative and inflammatory mechanisms in women: results of a randomized controlled trial. Cytokine. 2018;102:18-25. http://doi.org/10.1016/j.cyto.2017.12.016.

Jani B, Marsicano E. Constipation: Evaluation and Management. Mo Med. 2018 May-Jun;115(3):236-40.

Lacy BE, Levenick JM, Crowell M. Chronic constipation: new diagnostic and treatment approaches. Therap Adv Gastroenterol. 2012 Jul;5(4):233-47. http://doi.org/10.1177/1756283X12443093.

Leshchyshyn IM, Byk PL, Plodienko M, et al. Histological changes in the colon wall in adult patients with chronic slow-transit constipation. General Surgery. 2023;(2).

Marquis P, De La Loge C, Dubois D, McDermott A, Chassany O. Development and validation of the Patient Assessment of Constipation Quality of Life questionnaire. Scand J Gastroenterol. 2005;40:540-51. http://doi.org/10.1080/00365520510012208.

Mearin F, Lacy BE, Chang L, Chey WD, Lembo AJ, Simren M, Spiller R.. Bowel disorders. Gastroenterology. 2016 Feb 18:S0016-5085(16)00222-5. http://doi.org/10.1053/j.gastro.2016.02.031.

Ohkubo H, Yoshihara T, Misawa N, Ashikari K, Fuyuki A, Matsuura T, Higurashi T, Imajo K, Hosono K, Yoneda M, Kobayashi N, Saito S, Nakajima A. Relationship between stool form and quality of life in patients with chronic constipation: An Internet Questionnaire survey. Digestion. 2021;102(2):147-54. https://doi.org/10.1159/000502815.

Palsson OS, Whitehead WE, van Tilburg MA, Chang L, Chey W, Crowell MD, Keefer L, Lembo AJ, Parkman HP, Rao SS, Sperber A, Spiegel B, Tack J, Vanner S, Walker LS, Whorwell P, Yang Y. Development and Validation of the Rome IV Diagnostic Questionnaire for Adults. Gastroenterology. 2016;150(6):1481-91. Feb 13:S0016-5085(16)00180-3. http://doi.org/10.1053/j.gastro.2016.02.014.

Rao SS, Bharucha AE, Chiarioni G, Felt-Bersma R, Knowles C, Malcolm A, Wald A. Anorectal disorders. Gastroenterology. 2016;150(6):1430-42. http://doi.org/10.1053/j.gastro.2016.02.009.

Ruiz-López MC, Coss-Adame E. Quality of life in patients with different constipation subtypes based on the Rome III criteria. Revista de Gastroenterología de México. 2015;80(1):13-20. http://doi.org/10.1016/j.rgmx.2015.01.003.

Shokouhi N, Mohammadi S, Ghanbari Z, Montazeri A. Development of a new version of the Bristol Stool Form Scale: translation, content validity, face validity, and reliability of the Persian version. BMJ Open Gastroenterol. 2022;9(1):e001017. http://doi.org/10.1136/bmjgast-2022-001017.

Suares NC, Ford AC. Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol. 2011;106(9):1582-91. quiz 1581, 1592. http://doi.org/10.1038/ajg.2011.164.

Suares NC, Ford AC. Systematic review: the effects of fibre in the management of chronic idiopathic constipation. Aliment Pharmacol Ther. 2011;33(8):895-901. http://doi.org/10.1111/j.1365-2036.2011.04602.x.

Yiannakou Y, Tack J, Piessevaux H, Dubois D, Quigley EMM, Ke MY, Da Silva S, Joseph A, Kerstens R. The PAC-SYM questionnaire for chronic constipation: defining the minimal important difference. Aliment Pharmacol Ther. 2017 Dec;46(11-12):1103-11). http://doi.org/10.1111/apt.14349.

Downloads

Published

2024-06-30

How to Cite

1.
Leshchyshyn I, Markulan L, Okhotska O, Byk P. Quality of life in patients with chronic slow-transit constipation according to the PAC-QOL questionnaire and the effectiveness of conservative therapy. ЗХ [Internet]. 2024Jun.30 [cited 2024Oct.30];(2):18-26. Available from: http://generalsurgery.com.ua/article/view/308061

Issue

Section

Original Research