The shape and volume restoration of the mammary glands in postoperative deformations
DOI:
https://doi.org/10.30978/GS-2025-3-61Keywords:
breast reconstruction, postoperative deformities, autologous flaps, breast symmetry, nipple‑areolar complex, 3D breast imaging, MRI volumetryAbstract
This article is dedicated to modern methods of reconstructive and plastic breast surgery in women with postoperative deformities. Reconstruction of the mammary glands in cases of postoperative deformities relies on a variety of surgical techniques. The selection of an appropriate method depends on the morphological characteristics of the defect, tissue condition, prior surgical history, and the patient’s overall somatic status. The article highlights the anatomical and aesthetic parameters of the mammary glands, the classification of postoperative deformities, and modern approaches to secondary reconstruction (implants, autologous tissues, lipofilling), the importance of preserving or restoring the nippleareolar complex, as well as methods for objective measurement of breast shape and volume, including 3D scanning, magnetic resonance imaging (MRI), and mathematical models. The main approaches to reconstruction are discussed: implants, tissue expanders, autologous flaps (DIEP, TRAM, TDAP, SGAP, LICAP), and lipofilling as an additional or independent option for minor defects. Their advantages, disadvantages, and indications are analyzed. Special attention is given to breast symmetry, the influence of individual anatomical features of the patient, and the staging of surgical interventions. It is emphasized that early reconstruction after mastectomy contributes to better psychological rehabilitation, and the restoration of the breast’s aesthetic units improves patients’ quality of life. MRI is identified as the most accurate method for assessing breast volume, although less invasive and more accessible methods are preferred in routine practice. The article summarizes current approaches to the planning and execution of secondary reconstructive surgery for restoring breast shape, volume, and symmetry. The importance of an individualized approach is emphasized to achieve optimal aesthetic and functional outcomes.
References
Avashia YJ, Desrosiers AE 3rd, Flores JI. A second superior gluteal artery perforator flap with previous liposuction to the same breast after resection of initial SGAP breast reconstruction due to cancer recurrence. Microsurgery. 2012 Sep;32(6):482-4. http://doi.org/10.1002/micr.21989. Epub 2012 Jun 20. PMID: 22718270.
Bayti T, Panouilleres M, Tropet Y, Bonnetain F, Pauchot J. [Fat grafting in breast reconstruction. Retrospective study of satisfaction and quality of life about 68 patients]. Ann Chir Plast Esthet. 2016 Jun;61(3):190-9. French. http://doi.org/10.1016/j.anplas.2015.09.004. Epub 2015 Oct 23. PMID: 26603209.
Biazus JV, Falcão CC, Parizotto AC, Stumpf CC, Cavalheiro JA, Schuh F, Cericatto R, Zucatto ÂE, Melo MP. Immediate Reconstruction with Autologous fat Transfer Following Breast-Conserving Surgery. Breast J. 2015 May-Jun;21(3):268-75. http://doi.org/10.1111/tbj.12397. Epub 2015 Mar 17. PMID: 25783210.
Bitik O, Uzun H. Analysis of Lower Breast Pole Length and Nipple-Areola Complex Position Following Superior Pedicle, Short Horizontal Scar Breast Reduction. Aesthetic Plast Surg. 2016 Oct;40(5):690-8. http://doi.org/10.1007/s00266-016-0663-4. Epub 2016 Jun 29. PMID: 27357632.
Bresser PJ, Seynaeve C, Van Gool AR, Brekelmans CT, Meijers-Heijboer H, van Geel AN, Menke-Pluijmers MB, Duivenvoorden HJ, Klijn JG, Tibben A. Satisfaction with prophylactic mastectomy and breast reconstruction in genetically predisposed women. Plast Reconstr Surg. 2006 May;117(6):1675-82; discussion 1683-4. http://doi.org/10.1097/01.prs.0000217383.99038.f5. PMID: 16651934.
Cevik J, Rostek M, Rozen WM. Anomalous anatomic variation of an absent deep inferior epigastric artery: implications for autologous breast reconstruction. Surg Radiol Anat. 2024 Oct;46(10):1683-1686. http://doi.org/10.1007/s00276-024-03441-7. Epub 2024 Aug 6. PMID: 39105777.
Choppin SB, Wheat JS, Gee M, Goyal A. The accuracy of breast volume measurement methods: A systematic review. Breast. 2016 Aug;28:121-9. http://doi.org/10.1016/j.breast.2016.05.010. Epub 2016 Jun 9. PMID: 27288864.
Chrelias T, Berkane Y, Rousson E, Uygun K, Meunier B, Kartheuser A, Watier E, Duisit J, Bertheuil N. Gluteal Propeller Perforator Flaps: A Paradigm Shift in Abdominoperineal Amputation Reconstruction. J Clin Med. 2023 Jun 13;12(12):4014. http://doi.org/10.3390/jcm12124014. PMID: 37373707; PMCID: PMC10299709.
Colwell AS, Taylor EM. Recent Advances in Implant-Based Breast Reconstruction. Plast Reconstr Surg. 2020 Feb;145(2):421e-432e. http://doi.org/10.1097/PRS.0000000000006510. PMID: 31985660.
Damin AP, Tiellet BQ, de Melo MP, Zucatto AE, Cericatto R, Biazus JV. Case report of the combination of a TRAM flap, lipofilling, and 3D tattooing after failed implant-based reconstruction: improving aesthetic results. J Surg Case Rep. 2024 Sep 11;2024(9):rjae581. http://doi.org/10.1093/jscr/rjae581. PMID: 39262576; PMCID: PMC11388521.
Eterno V, Zambelli A, Pavesi L, Villani L, Zanini V, Petrolo G, Manera S, Tuscano A, Amato A. Adipose-derived Mesenchymal Stem Cells (ASCs) may favour breast cancer recurrence via HGF/c-Met signaling. Oncotarget. 2014 Feb 15;5(3):613-33. http://doi.org/10.18632/oncotarget.1359. PMID: 24327602; PMCID: PMC3996669.
Fong A, Park HS, Ross DA, Rozen WM. Preoperative planning of unilateral breast reconstruction with pedicled transverse rectus abdominis myocutaneous (TRAM) flaps: a pilot study of perforator mapping. Gland Surg. 2023 Mar 31;12(3):366-373. http://doi.org/10.21037/gs-22-529. Epub 2023 Mar 13. PMID: 37057040; PMCID: PMC10086775.
Gabka CJ, Bohmert H. Plastic and Reconstructive Surgery of the Breast. 2nd ed. Stuttgart: Thieme; 2009.
Galych SP, Smolanka II, Dabizha OY, et al. Breast reconstruction by using free transplantation of TRAM-flap in various modifications in breast cancer: analysis of results and complications. Clinical Oncology. 2017;4(28): 42-47. Available from:. https://www.clinicaloncology.com.ua/article/20289/rekonstrukciya-grudi-s-ispolzovaniem-svobodnoj-peresadki-tram-loskuta-v-razlichnyx-modifikaciyax-pri-rake-grudnoj-zhelezy-analiz-rezultatov-i-oslozhnenij. Ukrainian.
Hakakian CS, Lockhart RA, Kulber DA, Aronowitz JA. Lateral Intercostal Artery Perforator Flap in Breast Reconstruction: A Simplified Pedicle Permits an Expanded Role. Ann Plast Surg. 2016 May;76 Suppl 3:S184-90. http://doi.org/10.1097/SAP.0000000000000752. PMID: 26914351.
Hamdi M, Van Landuyt K, Van Hedent E, Duyck P. Advances in autogenous breast reconstruction: the role of preoperative perforator mapping. Ann Plast Surg. 2007 Jan;58(1):18-26. http://doi.org/10.1097/01.sap.0000250710.79113.e2. PMID: 17197937.
Han WY, Kim DJ, Lee YS, Eom JS, Kim EK, Han HH. Acellular Dermal Matrix without Basement Membrane in Immediate Prepectoral Breast Reconstruction: A Randomized Controlled Trial. Plast Reconstr Surg. 2024 Oct 1;154(4):649e-655e. http://doi.org/10.1097/PRS.0000000000011117. Epub 2023 Oct 3. PMID: 39314097.
Jurševičs K, Jurševičs E, Krasiļņikova J, Šķesters A, Lece A, Skadiņš I. Antioxidant Status in Patients after Breast Mastopexy and Augmentation. Medicina (Kaunas). 2024 Jun 26;60(7):1046. http://doi.org/10.3390/medicina60071046. PMID: 39064475; PMCID: PMC11278537.
Keane AM, Chiang SN, Tao Y, Pierce A, Gagne J, Margenthaler JA, Tenenbaum MM, Myckatyn TM. Cortiva versus AlloDerm in Prepectoral and Partial Submuscular Implant-Based Breast Reconstruction: A Randomized Clinical Trial. Plast Reconstr Surg. 2024 Oct 1;154(4S):13S-26S. http://doi.org/10.1097/PRS.0000000000011244. Epub 2024 Sep 20. PMID: 38085977; PMCID: PMC11412571.
Kim H, Kang BJ, Kim SH, Kim HS, Cha ES. What we should know in mammography after reduction mammoplasty and mastopexy? Breast Cancer. 2015 Jul;22(4):391-8. http://doi.org/10.1007/s12282-013-0494-y. Epub 2013 Sep 3. PMID: 24000038.
Lee BT, Agarwal JP, Ascherman JA, Caterson SA, Gray DD, Hollenbeck ST, Khan SA, Loeding LD, Mahabir RC, Miller AS, Perdikis G, Schwartz JS, Sieling BA, Thoma A, Wolfman JA, Wright JL. Evidence-Based Clinical Practice Guideline: Autologous Breast Reconstruction with DIEP or Pedicled TRAM Abdominal Flaps. Plast Reconstr Surg. 2017 Nov;140(5):651e-664e. http://doi.org/10.1097/PRS.0000000000003768. PMID: 29068921.
Longo B, Farcomeni A, Ferri G, Campanale A, Sorotos M, Santanelli F. The BREAST-V: a unifying predictive formula for volume assessment in small, medium, and large breasts. Plast Reconstr Surg. 2013 Jul;132(1):1e-7e. http://doi.org/10.1097/PRS.0b013e318290f6bd. PMID: 23806950.
Losken A, Seify H, Denson DD, Paredes AA Jr, Carlson GW. Validating three-dimensional imaging of the breast. Ann Plast Surg. 2005 May;54(5):471-6; discussion 477-8. http://doi.org/10.1097/01.sap.0000155278.87790.a1. PMID: 15838205.
Markiewicz E, Fan X, Mustafi D, Zamora M, Roman BB, Jansen SA, Macleod K, Conzen SD, Karczmar GS. High resolution 3D MRI of mouse mammary glands with intraductal injection of contrast media. Magn Reson Imaging. 2015 Jan;33(1):161-5. http://doi.org/10.1016/j.mri.2014.08.035. Epub 2014 Aug 29. PMID: 25179139; PMCID: PMC4267960.
Mátrai Z, Gulyas G, Kovacs T, Kásler M. Principles and Practice of Oncoplastic Breast Surgery. Budapest: Medicina Publishing House Co., 2019.
Millen JC, Sibia U, Jackson K, Stern SL, Orozco JIJ, Fancher CE, Grumley J. Comparing Costs: Does Extreme Oncoplastic Breast-Conserving Surgery Confer a Cost Benefit When Compared with Mastectomy and Reconstruction? Ann Surg Oncol. 2024 Oct;31(11):7463-7470. http://doi.org/10.1245/s10434-024-15711-0. Epub 2024 Jul 10. Erratum in: Ann Surg Oncol. 2024 Oct;31(11):7473. http://doi.org/10.1245/s10434-024-15887-5. PMID: 38987370.
Moyer HR, Carlson GW, Styblo TM, Losken A. Three-dimensional digital evaluation of breast symmetry after breast conservation therapy. J Am Coll Surg. 2008 Aug;207(2):227-32. http://doi.org/10.1016/j.jamcollsurg.2008.02.012. Epub 2008 May 12. PMID: 18656051.
Oku K. Vectorized facial skin tightening: A study on the Thermal Thread Technique™ utilizing high-intensity, high-frequency, parallel ultrasound beam. Lasers Surg Med. 2024 Apr;56(4):355-360. http://doi.org/10.1002/lsm.23771. Epub 2024 Feb 27. PMID: 38411259.
Pominchuk DV, Lashchenko MV, Lashchenko VA. (). Use of lipofilling in reconstructive and plastic surgery for rehabilitation of patients after surgery for breast cancer. International Medical Jurnal. 2021;27(3):24-29. http://jnas.nbuv.gov.ua/article/UJRN-0001269722. Ukrainian.
Probst H, Choppin SB, Wheat JS, Harrison M, Goyal A. The development of a low cost 3D surface imaging system to measure breast volume: Defining minimum standards using an adapted Delphi consensus study. J Plast Reconstr Aesthet Surg. 2015 Dec;68(12):1770-2. http://doi.org/10.1016/j.bjps.2015.09.014. Epub 2015 Oct 9. PMID: 26454415.
Ribuffo D, Mosiello L, Abbaticchio D, Marcasciano M, Lo Torto F. Autologous breast augmentation combining the harvesting of the Anterior Intercostal Artery Perforator (AICAP) and Lateral Intercostal Artery Perforator (LICAP) flaps in massive weight loss patient: A case report. JPRAS Open. 2024 Jun 6;41:110-115. http://doi.org/10.1016/j.jpra.2024.05.013. PMID: 38984324; PMCID: PMC11231510.
Schülein S, Taylor KJ, Braun B, Heyl V, Zoche H, Peek A, Solbach C, Schott S, Blettner M, Klug SJ. Evaluation of the methodological quality of articles on autologous breast reconstruction. J Plast Reconstr Aesthet Surg. 2018 Sep;71(9):1286-1294. http://doi.org/10.1016/j.bjps.2018.05.010. Epub 2018 Jun 8. PMID: 30173715.
Shim S, Unkelbach J, Landsmann A, Boss A. Quantitative Study on the Breast Density and the Volume of the Mammary Gland According to the Patient’s Age and Breast Quadrant. Diagnostics (Basel). 2023 Oct 30;13(21):3343. http://doi.org/10.3390/diagnostics13213343. PMID: 37958239; PMCID: PMC10648521.
Smit JM, Plat VD, van Est MLQ, van der Velde S, Daams F, Negenborn VL. Clinical outcomes of breast reconstruction using omental flaps: A systematic review. JPRAS Open. 2024 Jul 31;42:10-21. http://doi.org/10.1016/j.jpra.2024.07.010. PMID: 39279848; PMCID: PMC11399463.
Steiner MN, Boone LH, Hayden L, Schumacher J, Arnold CE. Mastectomy in ten mares: indications, surgical technique, complications, and long-term outcome. J Am Vet Med Assoc. 2024 Jul 31;262(10):1397-1404. http://doi.org/10.2460/javma.24.05.0350. PMID: 39084242.
Stevens WG, Calobrace MB, Alizadeh K, Zeidler KR, Harrington JL, d’Incelli RC. Ten-year Core Study Data for Sientra’s Food and Drug Administration-Approved Round and Shaped Breast Implants with Cohesive Silicone Gel. Plast Reconstr Surg. 2018 Apr;141(4S Sientra Shaped and Round Cohesive Gel Implants):7S-19S. http://doi.org/10.1097/PRS.0000000000004350. PMID: 29595714.
Swanson E. Is There a Role for Textured Tissue Expanders in Breast Reconstruction? Ann Plast Surg. 2024 May 1;92(5):489-490. http://doi.org/10.1097/SAP.0000000000003782. Epub 2024 Jan 4. PMID: 38289010.
Tehranchi S, Karagiannis P, Oezdogan Y. Innovative Reuse of Breast Expander Capsules for Parietal Pleura Repair in DIEP Flap Surgeries. Aesthetic Plast Surg. 2025 Jun;49(11):3296-3297. http://doi.org/10.1007/s00266-024-04432-0. Epub 2024 Oct 1. PMID: 39354228.
Vanschoonbeek A, Fabre G, Nanhekhan L, Vandevoort M. Outcome after urgent microvascular revision of free DIEP, SIEA and SGAP flaps for autologous breast reconstruction. J Plast Reconstr Aesthet Surg. 2016 Dec;69(12):1598-1608. http://doi.org/10.1016/j.bjps.2016.09.017. Epub 2016 Sep 28. PMID: 27771262.
Wang XL, Liu LB, Song FM, Wang QY. Meta-analysis of the safety and factors contributing to complications of MS-TRAM, DIEP, and SIEA flaps for breast reconstruction. Aesthetic Plast Surg. 2014 Aug;38(4):681-91. http://doi.org/10.1007/s00266-014-0333-3. Epub 2014 Jun 6. PMID: 24902911.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Authors

This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
